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10,23,25 One cross-sectional study involving a cohort of patients with diverse causes of CKD showed that increased HIF pathway activity in the glomerular compartment was more common in patients with nephrosclerosis and was associated with decreased estimated glomerular filtration rate

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By increasing fibroblast activity, collagen formation, and blood vessel growth, it enhances recovery from injuries such as muscle tears, tendon ruptures, and ligament damage ( 3, 4 )